Onkologie. 2025:19(2):76-79 | DOI: 10.36290/xon.2025.016

Immunotherapy in the treatment of metastatic urothelial carcinoma

Martina Spisarová, Andrea Kopová
Onkologická klinika, Fakultní nemocnice Olomouc
Lékařská fakulta Univerzity Palackého v Olomouci

Urothelial carcinoma is one of the most common cancers in its early stages. Oncologists, however, more frequently encounter patients with advanced disease. Unresec­table or metastatic urothelial carcinoma remains a significant therapeutic challenge. Traditional treatment has long relied on platinum-based chemotherapy. In recent years, this approach has evolved with the introduction of checkpoint inhibitors. A breakthrough came with combination immunotherapy regimens involving antibody-drug conjugates. The combination of pembrolizumab and enfortumab vedotin has redefined first-line treatment recommendations for urothelial carcinoma. Combination therapy is poised to become the future of urothelial carcinoma management, mirroring trends seen in the treatment of other cancers.

Keywords: immunotherapy, urothelial carcinoma, bladder cancer, immune check­point inhibitors.

Accepted: April 25, 2025; Published: May 2, 2025  Show citation

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Spisarová M, Kopová A. Immunotherapy in the treatment of metastatic urothelial carcinoma. Onkologie. 2025;19(2):76-79. doi: 10.36290/xon.2025.016.
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