Onkologie 2022: 16(Suppl.B): 57-60 | DOI: 10.36290/xon.2022.056

Necrobiotic xanthogranuloma and monoclonal gammopathy

MUDr. Viera Sandecká, Ph.D.

Interní hematologická a onkologická klinika, LF MU a FN Brno

Necrobiotic xanthogranuloma is a progressive and destructive disease associated with paraproteinemia, multiple organ involvement, and an increased risk of developing lymphoproliferative malignancy, such as multiple myeloma, chronic lymphocytic leukemia, or Hodgkin and non-Hodgkin lymphoma. The present article describes a complicated case of a female patient diagnosed with multiple myeloma and necrobiotic xanthogranuloma whose serious health complications were not typical for the diagnosis of multiple myeloma. A thorough diagnostic algorithm and multidisciplinary cooperation of various experts led to the definitive diagnosis. The article also includes a description of the treatment strategy using combination therapy of daratumumab plus lenalidomide and dexamethasone with intravenous administration of immunoglobulins.

Keywords: mnohočetný myelom, nekrobiotický xantogranulom, monoklonální protein, monoklonální gamapatie.

Accepted: October 4, 2022; Published: October 14, 2022  Show citation