Onkologie. 2024:18(4):271-274 | DOI: 10.36290/xon.2024.056
Fanconi syndrome after ifosfamide administration in a patient with Ewing sarcoma
- Klinikum Chemnitz, Klinik für Innere Medizin III, Chemnitz, Německo
Ifosfamide is an anticancer drug from the group of alkylating cytostatics that disrupts the replication of nucleotide chains by incorporating an alkyl group into the DNA chain. Although it is a historical drug dating back to the 1970s, it is still commonly encountered in cancer treatment, e. g. in bone tumours, sarcomas and recurrent non-Hodgkin's lymphomas or CNS lymphomas. This therapy is burdened with a number of adverse effects, of the classic acute side effects include reversible encephalopathy and hemorrhagic cystitis. In this case report, I would like to focus on the renal toxicity of ifosfamide or damage to the proximal tubule, which may result in the development of Fanconi syndrome.
Keywords: ifosfamide, Ewing's sarcoma, tubulopathy, Fanconi syndrome, metabolic acidosis.
Accepted: October 1, 2024; Published: October 7, 2024 Show citation
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