Onkologie. 2024:18(3):174-179 | DOI: 10.36290/xon.2024.032

Olaparib for the treatment of metastatic prostate cancer

Otakar Čapoun
Urologická klinika, VFN a 1. LF UK, Praha

About a quarter of men with metastatic castration-resistant prostate cancer (mCRPC) have a mutation in one of the genes involved in DNA repair through homologous recombination. The protein group poly (ADP-ribose) polymerase (PARP) can be blocked using so-called PARP inhibitors and DNA repair will not be done. The first PARP inhibitor approved for the treatment of mCRPC progressing after treatment with abiraterone or enzalutamide is olaparib. In addition, in combination with abiraterone, we can use it already in the first line, when mCRPC progresses on standard hormonal treatment.

Keywords: PARP inhibitors, olaparib, castration-resistant prostate cancer.

Accepted: June 18, 2024; Published: June 24, 2024  Show citation

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Čapoun O. Olaparib for the treatment of metastatic prostate cancer. Onkologie. 2024;18(3):174-179. doi: 10.36290/xon.2024.032.
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