Onkologie. 2017:11(5):248-255 | DOI: 10.36290/xon.2017.047

Smooth muscle tumors of the uterus of uncertain malignant potential

Monika Náležinská¹, Petr Škapa³, Jiří Špaček², Josef Chovanec¹

¹ Klinika operační onkologie Masarykova onkologického ústavu a LF Masarykovy univerzity v Brně

² Porodnická a gynekologická klinika LF Univerzity Karlovy a FN Hradec Králové

³ Ústav patologie a molekulární medicíny 2. LF Univerzity Karlovy a FN Motol, Praha

Objective: To summarize up to date knowledge of the uterine smooth muscle tumors of uncertain malignat potential and todefine specific predictors of the clinical outcome and to recomend therapeutic guidelines as well as the follow-up regimen.

Method: Overview study focused on stratification of the uterine smooth muscle tumors of uncertain malignant potential.

Conclusion: Smooth muscle tumours of uncertain malignant potential (STUMP) are rare tumors. The histological diagnosis is mostlypost-operative. The conclusion of histological analysis should predict the clinical outcome based on defined prognostic factors. Thesmall sample size of all reported studies is the reason for highly individual therapeutic and follow-up regimen. Generaly the recurrencerisk is low and clinical outcomes are favourable. As such, clinical expectant management does not seem to be unreasonable.

Keywords: STUMP (smooth muscle tumours of uncertain malignant potential), uterine leiomyoma, leiomyosarcoma, histogenesis,histopathologic features, p53, p16, Ki-67, clinical outcome

Published: November 1, 2017  Show citation