Onkologie. 2017:11(5):228-230 | DOI: 10.36290/xon.2017.043

Care for BRCA1 and BRCA2 gene carriers from the gynecologist's point of view

Helena Kolářová

Klinika operační onkologie, Oddělení gynekologické onkologie, Masarykův onkologický ústav

a Lékařská fakulta Masarykovy univerzity Brno

The article deals with the issue of care for BRCA1 and BRCA2 gene carriers, it means women with hereditary disposition for breastand ovarian cancer, from the gynecologist's point of view, and summarizes the recommendations for the dispensarization andthe implementation of preventive surgical procedures – adnexectomy with hysterectomy. The importance of caring for BRCA1,2gene mutations is emphasized with regard to the severity of ovarian carcinoma. The article draws attention to the fact that, accordingto the NCCN-modified indication criteria from 2015 and approved by the Society of Medical Genetics and Genomics ofthe ČLS JEP, genetic testing for all women with ovarian carcinoma without age and histological limitation is indicated to providedata for targeted cancer treatment using the inhibitors of PARP-poly (ADP-ribose) polymerase and to increase the detection ofmutations in affected families.

Keywords: hereditary breast and ovarian cancer syndrome, mutation of BRCA1 gene, mutation of BRCA2 gene

Published: November 1, 2017  Show citation