Onkologie. 2016:10(5):218-223 | DOI: 10.36290/xon.2016.047

Pediatric GIST

Viera Bajčiová
Klinika dětské onkologie FN a LF MU Brno

Pediatric GIST is an extremly rare tumor that differs from the adult GIST its molecular-genetic analysis, pathogenesis and associated

syndromes, clinical behavior and response to biology therapy. This article presents an overview of the molecular classification of

wild type pediatric GIST and its importance for clinical practice.

Keywords: gastrointestinal stromal tumor, pediatric tumor, KIT/PDGFR exprese, wild-type tumor

Published: November 1, 2016  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Bajčiová V. Pediatric GIST. Onkologie. 2016;10(5):218-223. doi: 10.36290/xon.2016.047.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Pappo AS, Janeway K, Laquaglia M, et al. Special considerations in pediatric gastrointestinal stromal tumors. J Surg Oncol 2011; 104(8): 928-932. Go to original source... Go to PubMed...
    2. Boikos SA, Stratakis CA. The genetic landscape of GITlacking KIT and PDGFRA mutations. Endocrine 2014; 47(2): 401-408. Go to original source... Go to PubMed...
    3. Demetri GD, Benjamin RS, Blanke ChD, et al. NCCN task force report: management of patients with gastrointestinal stromal tumors (GIST) - update of the NCCN clinical practice guidelines. J Nat Comprehen Cancer Network 2007; 5(Suppl. 2): 1-29. Go to original source... Go to PubMed...
    4. Kanthan R, Senger JL, Ahmed S, et al. Gastrointestinal stromal tumors in the 21st century. J Cancer Therapy 2014; 5: 769-796. Go to original source...
    5. Benesch M, Wardelmann E, Ferrari A, et al. Gatrointestinal stromal tumors (GIST) in children and adolescents: a comprehensive review of the literature. Pediatr Blood Cancer 2009; 53(7): 1171-1179. Go to original source... Go to PubMed...
    6. Prakash S, Sarran L, Socci N, et al. Gastrointestinal stromal tumors in children and young adults: a clinicopathologic, molecular and genomic study of 15 cases and review of the literature. J Pediatr Hematol Oncol 2005; 27(4): 179-187. Go to original source... Go to PubMed...
    7. Miettinen M, Lasota J, Sobin LH. Gastrointestinal stromal tumors of the stomach in children and young adults: a clinicopathologic, immunohistochemical and molecular genetic study of 44 cases with long-term follow-up and review of the literature. Am J Surg Pathol 2005; 29(10): 1373-1381. Go to original source... Go to PubMed...
    8. Agaram NP, Laquaglia M, Ustun B, et al. Molecular characterisation of pediatric gastrointestinal stromal tumors. Clin Cancer Res 2008; 14(10): 3204-3215. Go to original source... Go to PubMed...
    9. Janeway KA, Weldon CB. Pediatric gastrointestinal stromal tumor. Semin Pediatr Surg 2012; 21(1): 31-43. Go to original source... Go to PubMed...
    10. Janeway KA, Pappo A. Treatment guidelines for gastrointestinal stromal tumors in children and young adults. Pediatr Hematol Oncol 2012; 34(Suppl 2): 69-72. Go to original source... Go to PubMed...
    11. Wada R, Arai H, Kure S, et al. "Wild-type" GIST: clinicopathological features and clinical practice. Patology International 2016; 66: 431-437. Go to original source... Go to PubMed...
    12. Stratakis CA, Carney JA. The triad of paragangliomas, gastric stromal tumours and pulmonary chondromas (Carney triad) and the Hyad of paragangliomas and gastric stromal sarcomas (Carney-Stratakis syndrome): molecular genetics and clinical implications. J Intern Med 2009; 266(1): 43-52. Go to original source... Go to PubMed...
    13. Žiak D, Dvořáčková J, Hurník P, et al. Gastrointestinální stromální tumory, morfologická a imunohistochemická vyšetření z pohledu bioptického a cytologického odběru. Onkologie 2014; 8(6): 259-263.
    14. Jabeen S, Krishnasamy J, Kabal S et al: Sporadic pediatric GIST with novel gene mutation. J Med Cases 2013; 4(11): 722-725. Go to original source...
    15. Kim SY, Janeway KA, Pappo A. Pediatric and wildtype gastrointestinal stromal tumor (GIST): new therapeutic approaches. Curr Opin Oncol 2010; 22(4): 347-350. Go to original source... Go to PubMed...
    16. Dave M, Jimenez A, Evans K, et al. Treatment of recurrent pediatric gastrointestinal stromal tumors. Gastrointest Cancer Research 2012; 54): 139-140.
    17. Pantaleo MA, Nannini M, Corless Chl, et al. Quadruple wild-type (WT) GIST: defining the subset of GIST that lack abnormalities of KIT, PDGFRA, SDH or RAS signaling pathways. Cancer Med 2015; 4(1): 101-103. Go to original source... Go to PubMed...
    18. Comandone A, Boglione A. The importance of mutational status in prognosis and therapy of GIST. Precenti Prog Med 2015; 106(1): 17-22.
    19. Otto C, Agaimy A, Braun A, et al. Multifocal gastric gastrointestinal stromal tumors (GISTs) with lymph node metastases in children and young adults: a comparative clinical and histomorphological study of three cases including a new case of Carney triad. Diagn Pathol 2011; 52(6): 1-7. Go to original source... Go to PubMed...
    20. Price VE, Zielenska M, Chilton-MacNeill S, et al. Clinical and molecular characteristics of pediatric gastrointestinal stromal tumors (GISTs). Pediatr Blood Cancer 2005; 45: 20-24. Go to original source... Go to PubMed...
    21. Ricci R. Syndromic gastrointestinal stromal tumors. Hereditary Cancer in Clin Practice 2016; 14: 1-15. Go to original source... Go to PubMed...
    22. Patil DT, Rubin BP. Genetics of gastrointestinal stroma tumors: a heterogenous family of tumours? Surg Pathol Clin 2015; 8(3): 515-524. Go to original source... Go to PubMed...
    23. Blay J-Y, Casali PG, Dei Tos AP, et al. Management of gastrointestinal stromal tumour: current practices and visions for the future. Oncology 2015; 89: 1-13. Go to original source... Go to PubMed...
    24. Reichardt P, J-Y Blay, Boukovinas I, et al. Adjuvant therapy in primary GIST: state-of-the-art. Ann Oncol 2012; 23: 2776-2781. Go to original source... Go to PubMed...
    25. Nannini M, Astolfi A, Urbini M, et al. Integrated genomic study of quadrille-WT GIST (KIT/PDGFRA/SDH/RAS pathway wild-type GIST). BMC Cancer 2014;14: 685-697. Go to original source... Go to PubMed...
    26. Huss S, Elges S, Trautmann M, et al. Classification on KIT/PDGFRA wild-type gastrointestinal stromal tumors: implications for therapy. Expert Rev Anticancer Ther 2015; 15(6): 623-628. Go to original source... Go to PubMed...
    27. Oudijk L, Gaal J, Korpershoek E, et al. SDHA mutations in adult and pediatric wild-type gastrointestinal stromal tumors. Mod Pathol 2013; 26(3): 456-63. Go to original source... Go to PubMed...
    28. Sosipatros HB, Stratakis CA. The genetic landscape of gastrointestinal stromal tumors lacking KIT and PDGFRA mutations. Endocrine 2014; 47(2): 401-408. Go to original source... Go to PubMed...
    29. Rege TA, Wagner AJ, Corless CL, et al. "Pediatric-type" gastrointestinal stromal tumors in adults: distinctive histology predict genotype and clinical behavior. Am J Surg Pathol 2011; 35(4): 495-504. Go to original source... Go to PubMed...
    30. Kaemmer DA, Otto J, Lassay L, et al. The GIST of literature on pediatric GIST: review of clinical presentation. J Pediatr Hematom Oncol 2009; 31(2): 108-112. Go to original source... Go to PubMed...
    31. Zoundjiekpon V, Urban O, Rydlo M, et al. Diagnostika gastrointestinálních stromálních tumorů. Onkologie 2014; 8(6): 249-256.
    32. Uvírová M, Šimová J, Kubová B, et al. Molekulární genetika u gastrointestinálních stromálních tumorů. Onkologie 2014; 8(6): 257-258.
    33. The ESMO European Sarcoma Working Group: Gastrointestinal stromal tumors: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 2012; 23(Suppl 7): 49-55. Go to original source... Go to PubMed...
    34. Demetri GD, Reichardt P, Kang YK, et al. Efficacy and safety of regorafenib for advances gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled phase 3 trial. Lancet 2013; 381(9863): 295-302. Go to original source... Go to PubMed...
    35. Janeway KA, Albritton KH, Van Den Abbeele AD, et al. Sunitinib treatment in pediatric patients with advanced GIST following failure of Imatinib. Pediatr Blood Cancer 2009; 52: 767-771. Go to original source... Go to PubMed...
    36. Songdej N, von Mehren M. GIST treatment options after tyrosin kinase inhibitors. Curr Treat Options Oncology 2014; 15: 494-506. Go to original source... Go to PubMed...
    37. Berucci F, Finetti P, Mamessier E, et al. PDL1 expression in an independent prognostic factor in localised GIST. Oncoimmunology 2015; 4(5): e1002729. Go to original source... Go to PubMed...

    Return to the content


    Oncology

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.