Onkologie. 2016:10(3):138-141 | DOI: 10.36290/xon.2016.030
Treatment of laryngeal carcinoma
- Ústav radiační onkologie Nemocnice Na Bulovce a 1. LF UK, Praha
The goal of treatment of laryngeal carcinoma is to remove the tumor and prevent recurrence while maintaining laryngeal function.
Early-stage laryngeal carcinomas (stage I-II) are treated with either definitive radiation or surgery that preserves laryngeal
function. Randomised trials helped establish the basis of larynx preservation approaches 1st and 2nd generation using radiation
and chemotherapy in locoregionally advanced diseases (stage III-IV). Larynx preservation protocols provide equivalent tumor
control to surgery, while allowing a substantial number of patients to avoid the mutilating sequel of surgical treatment.
Keywords: laryngeal carcinoma, larynx preservation protocol, radiotherapy, neoadjuvant chemotherapy, concomitant chemoradiotherapy
Published: June 1, 2016 Show citation
References
- Li X, Gao L, Li H, et al. Human papillomavirus infection and laryngeal cancer risk: a systematic review and meta-analysis. J Infect Dis. 2013; 207: 479-488.
Go to original source... - Cohen SM, Garrett CG, Dupont WD, et al. Voice-related quality of life in T1 glottic cancer: irradiation versus endoscopic excision. Ann Otol Rhinol Laryngol 2006; 115: 581-586. Go to original source...
- Pála M, Holečková P, Veselá L, et al. Definitivní radioterapie v léčbě karcinomu glottis T1. Dlouhodobé výsledky ÚRO. 39. Brněnské onkologické dny. Brno 7.-10. 4. 2015.
- Department of Veterans Affairs Laryngeal Cancer Study Group: Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. N Engl J Med 1991; 324: 1685-1690. Go to original source...
- Lefebvre J, Chevalier D, Luboinski B, et al. Larynx preservation in pyriform sinus cancer: Preliminary results of a European Organization for Research and Treatment of Cancer phase III trial. J Natl Cancer Inst 1996; 88: 890-899. Go to original source...
Go to PubMed... - Pignon J, Bourhis J, Domenge C, et al. Chemotherapy added to locoregional treatment for head and neck squamous cell carcinoma: Three meta-analysis of updated individual data. Lancet 2000; 355: 949-955. Go to original source...
- Forastiere AA, Goepfert H, Maor M, et al. Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med 2003; 349: 2091-2098. Go to original source...
- Forastiere A, Maor M, Weber RS, et al. Long-term results of Intergroup RTOG 91-11: a Phase III trial to preserve the larynx-induction cisplatin/5-FU and radiation therapy versus concurrent cisplatin and radiation therapy versus radiation therapy. 42nd Annual Meeting of the American Society of Clinical Oncology. Atlanta, GA, USA, 2-6 June 2006. Go to original source...
- Janoray G, Pointreau Y, Garaud P, et al. Long-term results of GORTEC 2000-01: A multicentric randomized phase III trial of induction chemotherapy with cisplatin plus 5-fluorouracil, with or without docetaxel, for larynx preservation. J Clin Oncol 2015, 33(Suppl; abstr 6002). Go to original source...
- Lefebvre JL, Pointreau Y, Rolland F, et al. Induction chemotherapy followed by either chemoradiotherapy or bioradiotherapy for larynx preservation: the TREMPLIN randomized phase II study. J Clin Oncol 2013; 31: 853-859. Go to original source... Go to PubMed...
- Morton RP, Rugman F, Dorman EB, et al. Cisplatinum and bleomycin for advanced or recurrent squamous cell carcinoma of the head and neck: a randomised factorial phase III controlled trial. Cancer Chemother Pharmacol 1985; 15: 283-289. Go to original source... Go to PubMed...
- Vermorken JB, Hitt R, Geoff RL, et al. Cetuximab plus platinum-based therapy first-line in recurrent and/or metastatic squamous cell carcinoma of the head and neck: efficacy and safety results of a randomized phase III trial (EXTREME). Eur J Cancer 2007; 324(Suppl. 4): 5501. Go to original source...
- Hoffman HT, Porter K, Karnell LH, et al. Laryngeal cancer in the United States: changes in demographics, patterns of care, and survival. Laryngoscope 2006; 116: 113. Go to original source... Go to PubMed...
- LoTempio MM, Wang KH, Sadeghi A, et al. Comparison of quality of life outcomes in laryngeal cancer patients following chemoradiation vs. total laryngectomy. Otolaryngol Head Neck Surg 2005; 132: 948-953. Go to original source... Go to PubMed...