Onkologie. 2016:10(2):102-106 | DOI: 10.36290/xon.2016.023
Metastatic primary non-resectable colorectal cancer mimicking ovarian cancer in a 38-year old pregnant woman
- 1 Interní hematologická a onkologická klinika LF MU a FN Brno
- 2 Gynekologicko-porodnická klinika LF MU a FN Brno
- 3 Ústav patologie FN Brno
- 4 Oddělení nukleární medicíny, Masarykův onkologický ústav Brno
- 5 Radiodiagnostická klinika LF MU a FN Brno
- 6 Oddělení laboratorní medicíny, Masarykův onkologický ústav Brno
We report a very rare case of a 38-year old woman coming in for a planned gynaecological examination in 12th week of pregnancy
suffering from symptoms considered to be associated with her pregnancy. The ultrasound picture showed a missed pregnancy and
a suspicious ovarian cyst and the patient was referred to University Hospital Brno. After examination there was a strong suspicion for
ovarian cancer with ascites and peritoneal and liver metastases. The biopsy from a mass of posterior vaginal wall was performed and
pathologist's conclusion was grade II adenocarcinoma, possibly ovarian origin. Subsequently according to the immunohistochemical
analysis the pathologist recommended to examine possibility of colorectal origin of the tumour. The start of systemic therapy
was postponed and colonoscopy finding was a polypoid infiltration of sigmoid colon in 28 cm. Complementary circulating tumour
markers specific to colorectal cancer were highly elevated. The conclusion according to immunohistochemistry was moderately
differentiated adenocarcinoma most likely of colorectal origin. A diagnosis of a metastatic primary non-resectable colorectal cancer
was made and systemic chemotherapy in combination with biological therapy tailored to this type of cancer was administered.
Keywords: cancer in pregnancy, ovarian cancer, colorectal cancer, immunohistochemistry, keratin-20
Published: May 1, 2016 Show citation
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