Onkologie. 2016:10(2):92-97 | DOI: 10.36290/xon.2016.021

Neuromuscular symptomatology as primary manifestation of a malignant neoplasm and a phylogenetic importance

Jana Neuwirthová, Břetislav Gál, Pavel Smilek, Hana Binková, Pavla Urbánková, Rom Kostřica

Klinika otorinolaryngologie a chirurgie hlavy a krku, FN u sv. Anny v Brně

of behaviour changes induced by proinflamatory cytokines

Pro-inflammatory cytokines and hormonal changes in oncological diseases induce metabolic, neurological and psychic changes

which could be presented as first symptoms of an occult malignant neoplasm. Moreover, the production of several types of auto-

antibodies could make symptoms similar to autoimmune diseases. Specific behaviour changes due to pro-inflammatory signals

from the periphery are characteristic for all mammals and have their own phylogenetic importance, which have been developed

with wounded and sick animals in order to redistribute their energy resources to facilitate healing wounds and infections on the

one hand, and to induce hyper-vigilance against a future predator attack on the other hand.

Keywords: paraneoplastic symptom, sickness behaviour, pro-inflammatory cytokine, myalgia, insomnia, depression

Published: May 1, 2016  Show citation