Onkologie. 2015:9(1):19-21

Patogenesis of ethanol cancerogenity in head and neck carcinomas

Jana Neuwirthová1, Pavel Smilek1, Břetislav Gál1, Rom Kostřica1, Zdeněk Mechl2
1 Klinika otorinolaryngologie a chirurgie hlavy a krku, FN u sv. Anny v Brně
2 Klinika hematologie a onkologie, FN Brno

This article summarizes mechanisms through which ethanol promotes the genesis and growth of carcinomas of an upper aerodigestive

tract. Ethanol plays a role in cancerogenesis as a cocancerogen because it facilitates penetration of other cancerogens to cells.

However, ethanol also represents a direct cancerogen, because the cancerogenic acetaldehyde is formed of it. Ethanol can also promote

the tumor growth through immunosupression or hormonal disturbances.

Keywords: head and neck carcinomas, ethanol, acetaldehyde, alcohol dehydrogenase, aldehyde dehydrogenase, estrogens, androgens

Published: March 10, 2015  Show citation

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Neuwirthová J, Smilek P, Gál B, Kostřica R, Mechl Z. Patogenesis of ethanol cancerogenity in head and neck carcinomas. Onkologie. 2015;9(1):19-21.
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