Onkologie. 2014:8(2):64-71

Other neoplasms in survivors aged 0-49 years with gynaecological cancers

Edvard Geryk¹, Radim Štampach², Viera Bajčiová³, Teodor Horváth⁴

¹ Odbor vědy a výzkumu, Fakultní nemocnice, Brno

² Geografický ústav Přírodovědecké fakulty, Masarykova Univerzita Brno

³ Klinika dětské onkologie, Fakultní nemocnice, Brno

⁴ Chirurgická klinika Fakultní nemocnice, Brno

The neoplasms following primary cancers of cervix (CC), uterus (CU), ovary (CO), and primary neoplasms before these gynaecological cancers

(GC), were analyzed in a retrospective study in survived females aged 0–49 years, notified in the National Czech Cancer Registry between

1976 and 2010. A total 3,727 patients of these three diagnoses, presented 12.1 % of 30,794 newly registered GC, were associated with 4,160

other neoplasms. Their development was concerned with a) 1,339 females with primary CC, 715 with CU and 664 with CO (followed by 1,509

and 831, respectively 758 other neoplasms) and b) subsequent 263 CC, 212 CU and 534 CO (preceded by 274 and 223, respectively 565 primary

neoplasms). The average interval of occurrence of subsequent neoplasms was 14.2 years after CC, 13.6 years after CU and 10.2 years

after CO. The most frequent of 3.098 subsequent neoplasms were 21 % of digestive tract, 16 % breast, 13 % skin, 11.7 % female genital, 9.7 %

respiratory and 7.8 % urinary organs; the most frequent during the first year after primary GC were those of the ovarial, endometrial, cervical

and colorectal cancers. The most frequent of 1,062 primary neoplasms before GC were 26.7 % cancers of female genital organs, 24.3 %

breast and 14.8 % digestive tract. During 35 years the number of females with primary GC has decreased, especially of their representation

at the early clinical stages, the females with subsequent GC has increased, especially at the advanced stages. There were recorded early

stages in 70.4 % females with primary GC and 54 % with subsequent GC, advanced stages in 29.5 % females with subsequent GC and 13.3 %

with primary GC, the unknown stages included about 16.5 %. In our study are estimated about 1100 cases of advanced stages in females

aged 49 years survived with GC in 1976–2010. Most of the evaluated criteria were unfavorable among females with ovarian cancers. Mainly

the cases at advanced stages must be prevented by the dispensary guidelines and preventive interventions. Limited financial resources

and persistent risks of lifestyle do not allow to slow down the increase of primary and subsequent neoplasms in the near future among

cancer survivors not only in gynaecology.

Keywords: cancers of cervix uteri, corpus uteri and ovary, primary and subsequent neoplasms, clinical stages

Published: May 10, 2014  Show citation