Onkologie. 2014:8(2):54-60

Ovarian tumors in children and adolescent girls

Viera Bajčiová
Klinika dětské onkologie LF MU a Fakultní nemocnice Brno

Ovarian tumors are rare tumors in children, their incidence is much higher in adolescent girls. In generation younger than 20 years of the

age germ cell tumors are the commonest ovarian neoplasms. Epithelial tumors – carcinomas are extremly rare with less agressive clinical

behavior comparing with older women. Sex-cord stromal tumors are the most common cause of pseudopubertas praecox in girls.

The prognosis and outcome is very good, more than 90% of patients are long term survivors. This is a review of current knowledges of

ovarian tumors in young generation.

Keywords: ovarian tumors, pediatric age, adolescent age, germ cell tumor, carcinomas, borderline tumors

Published: May 10, 2014  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Bajčiová V. Ovarian tumors in children and adolescent girls. Onkologie. 2014;8(2):54-60.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Brown J, Olson T, et al. Malignancies of the ovary. Chapter 13 in Bleyer WA, Barr RD: Cancer in adolescents and young adults. Springer - Verlag Berlin 2007: 219-236. Go to original source...
    2. Hořejší J, Rob L. Malignant tumors of the female genitalia in childhood - yesterday, today and tomorrow. Cas Lek Cesk 2003; 142(2): 84-87. Go to PubMed...
    3. Chen Z, Robinson L, et al. Risk of childhood germ cell tumors in association with parental smoking and drinking. Cancer 2005; 103(5): 1064-1071. Go to original source... Go to PubMed...
    4. Cushing B, Perlman E, et al. Germ cell tumors, Chapter 36 in Pizzo PA, Poplack DG: Principles and practice of pediatric oncology. Lippincot Williams and Wilkins 2006, 5th edition: 1116-1138.
    5. Ozols RF, Rubin SC, Thomas G, et al. Epithelial ovarian cancer. In: Hoskins WJ, Perez CA, Young RC, eds. Principles and practice of Gynecologic Oncology, 4th ed, Philadelphia: Lippincott Williams & Wilkins. 2005: 919-922.
    6. DiSaia P, Craesman W. Epithelial ovarian cancer. Clinical Gynecologic Oncology, 6th eds: 289-350. Mosby 2002. Go to original source...
    7. Zhang M, Juany W, Li G, et al. Ovarian masses in children and adolescents - an analysis of 521 clinical cases. J Pediatr Adolesc Gynecol 2013; (13): 1083-3188.
    8. Imai A, Furui T, et al. Gynecologic tumors and symptoms in childhood and adolescence. Curr Opin Obstet Gynecol 2001; 13(5): 469-473. Go to original source... Go to PubMed...
    9. Garel L, Dubios J, et al. US of the pediatric female pelvis: a clinical perspective.RadioGraphics 2001; 21: 1393-1407. Go to original source... Go to PubMed...
    10. Gershenson DM. Management of ovarian germ cell tumors. J Clin Oncol 2007; 25(20): 2938-2943. Go to original source... Go to PubMed...
    11. Deligeoroglou E, Eleftheriades M, et al. Ovarian masses during adolescence: clinical, ultrasonographic and pathologic findings, serum tumor markers and endocrinological profile. Gynecol Endocrinol 2004; 19: 1-8. Go to original source... Go to PubMed...
    12. Jung SE, Lee JM, et al. CT and MRI imaging of ovarian tumors with emphasis on differential diagnosis. RadioGraphics 2002; 22: 1305-1325. Go to original source... Go to PubMed...
    13. Basu S, Rubeolo D. PET imaging in the management of tumors of testis and ovary: current thinking and future directions. Minerva Endocrinol 2008; 33(3): 229-256.
    14. Bajčiová V. Germinální nádory ovarií, kapitola 15. 1: 189-196, v monografii Bajčiová V, Štěrba J, Tomášek J: Nádory adolescentů a mladých dospělých, Grada 2011.
    15. Cadron I, Leunen K, et al. Management of borderline ovarian neoplasms. J Clin Oncol 2007; 25(20): 2928-2937. Go to original source... Go to PubMed...
    16. Hazard FK, Longacre TA. Ovaria surface epithelial neoplazma in the pediatric population: incidence, histologic subtypes and natural history. Am J Surg Pathol 2013; 37(4): 548-553. Go to original source... Go to PubMed...
    17. Hohne S, Milzsch M, Stiefel M, et al. Ovarian borderline tumors in pre-menarche girls. Pediatr Hematol Oncol 2013; 30(4): 253-262. Go to original source... Go to PubMed...
    18. Schneider DT, Schuster AE, et al. Genetic analysis of childhood germ cell tumors with comparative genomic hybridization. Klin Paediatr 2001; 4: 204-211. Go to original source... Go to PubMed...
    19. Zahn S, Siwevers S, et al. Imbalances of chromosome arm 1p in pediatric and adult germ cell tumors are cause by true allelic loss: a combined comparative genomic hydridization and microsatellite analysis. Genes Chromosomes Cancer 2006; 45(11): 995-1006. Go to original source... Go to PubMed...
    20. Perlman EJ Hu J, et al. Genetic analysis of childhood endodermal sinus tumors by comparative genomic hybridization. J Pediatr Hematol Oncol 2000; 22: 100-105. Go to original source... Go to PubMed...
    21. Oosterhuis JW, looijenga LHJ, et al. Testicular germ cell tumors in broader perspective.Nature Reviews 2005; 5: 210-222. Go to original source... Go to PubMed...
    22. Elashry R, Hemida R, Goda H, et al. Prognostic factors of germ cell and sex cord-stromal ovarian tumors in pediatric age: 5 years experience. J Exp Ther Oncol 2013; 10(3): 181-187.
    23. Spinelli C, Pucci V, Strambi S, et al. Treatment of ovarian lesions in children and adolescents: a retrospective study of 130 cases. Pediatr Hematol Oncol 2013; Nov 25. Go to original source... Go to PubMed...
    24. Barbancho DC, Novillo IC, et al. Laparoscopy for ovarian tumors in children. Cir Pediatr 2007; 20(1): 15-18. Go to PubMed...
    25. Ozcan R, Kuruoglu S, Dervisoglu S, et al. Ovary-sparing surgery for teratomas in children. Pediatr Surg Int 2013; 29(3): 233-237. Go to original source... Go to PubMed...
    26. Bajčiová V. Riziko rozvoje germinálních nádorů u pacientů s gonadální dysgenezí. Onkológia pre prax, 2010: 5(3): 152-155.
    27. Lee PA, Houk CHP, et al. Consensus statement on management of intersex disorders. Pediatrics 2006; 118: 488-500. Go to original source... Go to PubMed...
    28. Kaern J, Trope CG, Abeler VM, et al. A retrospective study of 370 borderline tumors of the ovary treated at the Norwegian Radium Hospital from 1970 to 1982. A review of clinipathologic features and treatment modalities. Cancer 1993; 71(5): 1810-1820. Go to original source...
    29. Tsai JY, Saigo PE, Brown C, et al. Diagnosis, pathology, staging, treatment, and outcome of epithelial ovarian neoplasia in patients age < 21 years. Cancer 2001; 91(11): 2065-2070. Go to original source...
    30. Dembo AJ, Davy M, Stenving AE, et al. Prognostic factors in patients with stage I epithelial ovarian cancer. Obstet Gynecol 1990; 75(2): 263-273. Go to PubMed...
    31. Bell J, Brady M, Lage J, et al. A randomized phase III trial ofthree versus six cycles of chemotherapy as adjuvant treatment in early stage ovarian epithelial carcinoma. A Gynecologic Oncology Group study. Proceedings of 34th Annual Meeting of The Society of Gynecologic Oncologists 2003: Abstract 1: 70.
    32. van den Burg ME, van Lent M, Buyse M, et al. The effect of debulking surgery after induction chemotherapy on the prognosis in the advanced epithelial ovarian cancer. Gynecological Cancer Cooperative Group of the European Organisation for Research and Treatment of Cancer. N Engl J Med 1995; 332: 629-634. Go to original source... Go to PubMed...

    Return to the content


    Oncology

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.