Onkologie. 2012:6(1):35-36
Neoadjuvant chemotherapy in a patient with low proliferation
- Klinika komplexní onkologické péče, MOÚ Brno
The goal of neoadjuvant chemotherapy is to improve surgical options and cosmetic outcome of surgery. Chemotherapy should be indicated
in tumours in which a therapeutic response can be expected, i.e. those with negative oestrogen receptors, higher proliferation,
higher grade and nonlobular histology. A case is reported of neoadjuvant chemotherapy in a female patient in whom the likelihood of
response to chemotherapy was low according to tumour phenotype obtained from Tru-Cut biopsy. However, the biological behaviour
of the tumour did not correspond to the tumour phenotype. The patient had an excellent response to chemotherapy. Several papers
report discordance of histological features from Tru-Cut biopsy and definitive histology, particularly in terms of tumour proliferation.
Keywords: neoadjuvant chemotherapy, Ki-67 proliferation, discordance
Published: February 29, 2012 Show citation
References
- Kaufmann M, von Minckwitz G, Bear HD, et al. Recommendation from an international expert panel on the use ofneoadjuvant (primary) systemic treatment of operable breast cancer: new perspectives 2006. Ann Oncol 2007; 18(12): 1927-1934.
- Ring AE, Smith IE, Ashley S, et al. Oestrogen receptor status, pathological complete response and prognosis in patients receiving neoadjuvant chemotherapy for early breast cancer. Br J Cancer 2004; 91: 2012-2017.
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