Onkologie. 2010:4(1):40-42

Antiangiogenic therapy in oncology

Peter Kružliak1, Jana Benkovičová2, Ján Šlapák3
1 Interné oddelenie NsP Bojnice
2 Onkologické oddelenie NsP Bojnice
3 Oddelenie pľúcnych chorôb NsP Bojnice

Antiangiogenic therapy currently represents one of the new exciting prospects in oncology. It is a treatment that is focused on suppression

of the release of proangiogenic factors produced in the cell or directed against the receptors for angiogenic factors on endothelial

cells. This paper explains the principles and current issues of antiangiogenic therapy.

Keywords: angiegenesis, antiangiogenic therapy, vaskular faktor (VEGF), growth faktor

Published: March 1, 2010  Show citation

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Kružliak P, Benkovičová J, Šlapák J. Antiangiogenic therapy in oncology. Onkologie. 2010;4(1):40-42.
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References

  1. Folkman J. Tumour angiogenesis: therapeutic implications. N Engl J Med 1971; 285: 1182-1186. Go to original source... Go to PubMed...
  2. Bergers G, Benjamin LE. Tumorigenesis and the angiogenic switch. Nature Rev 2003; 3: 401-409. Go to original source... Go to PubMed...
  3. Dvorak HF. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumour angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol 2002; 20: 4368-4380. Go to original source... Go to PubMed...
  4. Poon RT, Fan ST, Wong J. Clinical implication of circulating angiogenic factors in cancer patients. J Clin Oncol 2001; 19: 1207-12025. Go to original source... Go to PubMed...
  5. Kerbel R. Clinical translation of angiogenesis inhibitors. Nature Rev Cancer 2002; 2: 727-739. Go to original source... Go to PubMed...
  6. Garber K. Angiogenesis inhibitors suffer new setback. Nature Biotechnol 2002; 20: 1067-1068. Go to original source... Go to PubMed...
  7. Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350: 2406-2408. Go to original source... Go to PubMed...
  8. Ma J, Waxman DJ. Combination of antiangiogenesis with chemotherapy for more effective cancer treatment Mol. Cancer Ther 2008; 7: 3670-3684. Go to original source... Go to PubMed...
  9. Dome B, Timar J, Dobos J, et al. Identification and clinical significance of circulating endothelial progenitor cells in human non-small cell lung cancer. Cancer Res 2006; 66: 7341-7347. Go to original source... Go to PubMed...




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