Onkologie. 2009:3(4):254-257

Avascular necrosis of the femoral head in patient with diffuse large B-cell lymphoma treated with high dose immunochemotheraphy

Zuzana Kubová1, Antonín Hluší1, MUDr. Tomáš Papajík CSc1, Jan Špička2, Miroslav Mysliveček3, Karel Indrák1
1 Hemato-onkologická klinika FN a LF UP v Olomouci
2 Ortopedická klinika LF UP a FN Olomouc
3 Klinika nukleární medicíny FN a LF UP v Olomouci

Corticosteroid-induced avascular necrosis (AVN) of the femoral head is a rare, but well-known complication of lymphoma and leukemia



treatment: It is a pathological process characterized by impaired microcirculation with subsequent ischaemia which gradually leads to

necrosis of the bone segment. There is the case report of young patient with primary mediastinal diffuse large B-cell lymphoma described.

She was treated with sequential immunochemotherapy with intermittent administration of high dose corticosteroids. In 106 days

after initiation of therapy AVN of the left femoral head was observed.

Keywords: avascular necrosis of the temoral head, diffuse large B-cell lymphoma, corticosteroids.

Published: November 1, 2009  Show citation

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Kubová Z, Hluší A, Papajík T, Špička J, Mysliveček M, Indrák K. Avascular necrosis of the femoral head in patient with diffuse large B-cell lymphoma treated with high dose immunochemotheraphy. Onkologie. 2009;3(4):254-257.
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